Selection of Salmonella phage strains for the creation of a therapeutic and prophylactic drug against salmonellosis in piglets

Relevance. Bacteriophage preparations are a promising tool for the prevention and treatment of zoonoses. The effectiveness use phage at different stages food production has been proven: in cultivation animals, processing their slaughter products sanitation finished from causative agent salmonellosis. creation an effective capable protecting piglets salmonellosis during period high risk infection weaning is urgent task. Methods. To study properties bacteriophages, methods were used to determine: lytic activity (according Appelman Grazia), spectrum action, range specificity, frequency formation phage-resistant forms, bacterial strains selected reproduction. selection that manufacture preparation based on them pig was carried out according criteria recommended industrial bacteriophages. Results. A collection 24 virulent Salmonella phages formed. biological made it possible select 4 bacteriophages basis drug against swine